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验证数据展示

  • FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

    FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

    1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-3RB/CD131 Rabbit Recombinant Antibody (98232-1-RR, Clone: 241954C1) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD11b (M1/70) (CL647-65055, Clone: M1/70). Cells were not fixed. This data was developed using the same antibody clone with 98232-1-PBS in a different storage buffer formulation.

  • FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

    FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

    1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-3RB/CD131 Rabbit Recombinant Antibody (98232-1-RR, Clone: 241954C1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98232-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98232-1-RR

    Affinity and Kinetic Characterization of 98232-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98232-1-RR against Mouse IL-3RB/CD131 were performed. The affinity constant is below 1 pM.

Anti-Mouse IL-3RB/CD131 Rabbit Recombinant Antibody, PBS Only

IL-3RB/CD131 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98232-1-PBS

产品说明书

CloneNo. 241954C1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

Cytokine receptor common subunit beta, Csf2rb1, Csf2rb, CD131, Aic2b

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98232-1-PBS targets IL-3RB/CD131 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
别名 Cytokine receptor common subunit beta, Csf2rb1, Csf2rb, CD131, Aic2b
计算分子量99kDa
GenBank蛋白编号NM_007780.4
基因名称 IL-3RB/CD131
Gene ID (NCBI) 12983
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP26955
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD131, also known as IL-3RB, IL-5RB, colony stimulating factor 2 receptor subunit beta (CSF2RB), or cytokine receptor common subunit beta, is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 and IL-5 (PMID: 36532080). It is expressed predominantly by hematopoietic cells but also by non-hematopoietic cells (PMID: 10582335). CD131 mediates intracellular signaling by JAK2, leading to phosphorylation of CD131 and triggering signaling pathways such as STAT5, MAPK and PI3-Kinase/AKT which regulate cell survival, proliferation and function (PMID: 23535386).