验证数据展示
产品信息
33621-1-PBS targets CRYBA4 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag39089 Product name: Recombinant human CRYBA4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-150 aa of BC069404 Sequence: MTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWV 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | crystallin, beta A4 |
| 别名 | Beta A4 crystallin, Beta crystallin A4, crystallin, beta A4 |
| 计算分子量 | 196 aa, 22 kDa |
| 观测分子量 | 22 kDa |
| GenBank蛋白编号 | BC069404 |
| 基因名称 | CRYBA4 |
| Gene ID (NCBI) | 1413 |
| RRID | AB_3743031 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | P53673 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CRYBA4, also called βA4-crystallin, is the dominant structural components of the vertebrate eye lens (PMID: 16960806). Missense mutations of CRYBA4 (e.g., p.R95W, p.V150D) predicted to be highly pathogenic are linked with autosomal-dominant congenital cataract, indicating that both crystallin aggregation and non-lens signaling functions merit therapeutic targeting (PMID: 31935276).
