验证数据展示
发表文章中的应用
| IHC | See 1 publications below |
产品信息
66763-1-PBS targets CRM1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, Indirect ELISA Application Description |
| 文献引用应用 | IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human |
| 免疫原 | CRM1 fusion protein Ag27337 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | exportin 1 (CRM1 homolog, yeast) |
| 别名 | XPO1, 2D3B6, Exp1, Exportin 1, Exportin-1 |
| 计算分子量 | 1071 aa, 123 kDa |
| 观测分子量 | 100-110 kDa |
| GenBank蛋白编号 | BC032847 |
| 基因名称 | CRM1 |
| Gene ID (NCBI) | 7514 |
| RRID | AB_2882109 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O14980 |
| 储存缓冲液 | PBS only{{ptg:BufferTemp}}7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).
