CoraLite®594-conjugated COMMD1 Monoclonal antibody
COMMD1 Monoclonal Antibody for IF/ICC
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat, Pig
Applications
IF/ICC
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
3B10E10
验证数据展示
经过测试的应用
| Positive IF detected in | HepG2 cells |
Planning an IHC experiment? We recommend our IHCeasy COMMD1 Ready-To-Use IHC Kit. COMMD1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 67016-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| Immunofluorescence (IF) | IF : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL594-67016 targets COMMD1 in IF applications and shows reactivity with Human, Mouse, Rat, Pig samples.
| Tested Applications | IF/ICC |
| Tested Reactivity | Human, Mouse, Rat, Pig |
| Immunogen | COMMD1 fusion protein Ag28596 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | copper metabolism (Murr1) domain containing 1 |
| Synonyms | C2orf5, COMMD1, MURR1, Protein Murr1 |
| Calculated Molecular Weight | 190 aa, 21 kDa |
| Observed Molecular Weight | 18 kDa |
| GenBank Accession Number | BC022046 |
| Gene Symbol | COMMD1 |
| Gene ID (NCBI) | 150684 |
| RRID | AB_2920071 |
| Conjugate | CoraLite®594 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q8N668 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. |
背景介绍
COMMD1(COMM domain-containing protein 1), also named MURR1, is implicated in copper homeostasis by binding one copper ion per monomer. COMMD1 was reported to accelerate the ubiquitination and degradation of NF-kappa-B subunits, its deficiency exerts enhanced NF-kappa-B mediated celluar response. Ubiquitinated by XIAP (X-linked inhibitor of apoptosis), COMMD1 undergoes proteasomal degradation. SOD1 activity can be downregulated by COMMD1.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for CL594 COMMD1 antibody CL594-67016 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |