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验证数据展示

  • WB analysis using 14935-1-AP (same clone as 14935-1-PBS)

    WB analysis using 14935-1-AP (same clone as 14935-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14935-1-AP (CLIC2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14935-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 14935-1-AP (same clone as 14935-1-PBS)

    IHC staining of human liver using 14935-1-AP (same clone as 14935-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 14935-1-AP (CLIC2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14935-1-PBS in a different storage buffer formulation.

CLIC2 Polyclonal antibody, PBS Only

CLIC2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 14935-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

XAP121

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14935-1-PBS targets CLIC2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag6766

Product name: Recombinant human CLIC2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-210 aa of BC005367

Sequence: MILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chloride intracellular channel 2
别名 XAP121
计算分子量 28 kDa
观测分子量28-30 kDa
GenBank蛋白编号BC005367
基因名称 CLIC2
Gene ID (NCBI) 1193
RRIDAB_3669195
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15247
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CLIC2 (chloride intracellular channel 2), also known as CLCNL2. It is expected to be located in cytoplasm and membrane. CLIC-2 exists as a monomer. It also has an unusual enzyme activity profile. While the CXXC active site motif is conserved between CLIC-2 and the glutaredoxins, no thiol transferase activity was detected. In contrast, low glutathione peroxidase activity was recorded. CLIC-2 was found to be widely distributed in tissues including heart and skeletal muscle. Functional studies showed that CLIC-2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles. The calculated molecular weight of CLIC2 is 28 kDa.

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