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CDDO-dhTFEA

CDDO-dhTFEA 是合成的齐墩果烷三萜化合物，可有效激活Nrf2并抑制促炎转录因子NF-κB。 它可以恢复高血压 (MAP)，提高 Nrf2 及其靶基因的表达，抑制 NF-κB 的活化和转化生长因子-β 途径，并减少慢性肾病 (CKD) 大鼠的肾小球硬化，间质纤维化和炎症。

CAS号

1191265-33-4

分子式

C33H45F3N2O3

主要靶点

NF-κB|Apoptosis|Nrf2

仅限科研使用

Cat No : CM10811

Print datasheet

Synonyms

Inhibitor|NFkB|inhibit|Keap1-Nrf2|CDDO dhTFEA|CDDOdhTFEA|CDDO-dhTFEA|Nuclear factor-κB|Nuclear factor-kappaB|NFκB|Nrf2|NF-κB|NF-kB|RTA dh 404|RTA dh404|RTA dh-404

验证数据展示

  • CAS No.: 1191265-33-4

    CDDO-dhTFEA
    CAS#: 1191265-33-4

产品信息

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).

CAS号 1191265-33-4
分子式 C33H45F3N2O3
主要靶点 NF-κB|Apoptosis|Nrf2
主要通路 免疫与炎症|NF-κB 信号通路
分子量 574.72
纯度 99.59%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 Inhibitor|NFkB|inhibit|Keap1-Nrf2|CDDO dhTFEA|CDDOdhTFEA|CDDO-dhTFEA|Nuclear factor-κB|Nuclear factor-kappaB|NFκB|Nrf2|NF-κB|NF-kB|RTA dh 404|RTA dh404|RTA dh-404

体内活性

CDDO-dhTFEA 在慢性肾病大鼠模型中恢复正常血压，提高Nrf2及其靶基因表达，减缓NF-κB和转化生长因子-β (transforming growth factor-β) 通路的激活，降低肾小球硬化、间质纤维化和炎症进程[2]。

溶解度

10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (17.4 mM);DMSO:250 mg/mL (434.99 mM);10% DMSO+90% Saline:< 10 mg/mL (17.4 mM)

参考文献

1.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.
2.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.

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