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CDDO-dhTFEA

CAS号

1191265-33-4

分子式

C33H45F3N2O3

主要靶点

Nrf2|Others|NF-κB

仅限科研使用

Cat No : CM10811

Print datasheet

Synonyms

inhibit|CDDOdhTFEA|CDDO-dhTFEA|CDDO dhTFEA|Keap1-Nrf2|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|Nrf2|NFkB|NF-kB|NF-κB|NFκB|RTA dh 404|RTA dh404|RTA dh-404

验证数据展示

  • CAS No.: 1191265-33-4

    CDDO-dhTFEA
    CAS#: 1191265-33-4

产品信息

CAS号 1191265-33-4
分子式 C33H45F3N2O3
主要靶点 Nrf2|Others|NF-κB
主要通路 免疫与炎症|NF-κB 信号通路
分子量 574.72
纯度 98.88%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|CDDOdhTFEA|CDDO-dhTFEA|CDDO dhTFEA|Keap1-Nrf2|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|Nrf2|NFkB|NF-kB|NF-κB|NFκB|RTA dh 404|RTA dh404|RTA dh-404

体内活性

CDDO-dhTFEA 在慢性肾病大鼠模型中恢复正常血压，提高Nrf2及其靶基因表达，减缓NF-κB和转化生长因子-β (transforming growth factor-β) 通路的激活，降低肾小球硬化、间质纤维化和炎症进程[2]。

溶解度

DMSO:100 mg/mL (174.00 mM)

参考文献

1.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.
2.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.

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