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验证数据展示

  • WB analysis using 66390-1-Ig (same clone as 66390-1-PBS)

    WB analysis using 66390-1-Ig (same clone as 66390-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66390-1-Ig (CD74 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66390-1-PBS in a different storage buffer formulation.

  • IF Staining of Raji using 66390-1-Ig (same clone as 66390-1-PBS)

    IF Staining of Raji using 66390-1-Ig (same clone as 66390-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Raji cells using CD74 antibody (66390-1-Ig, Clone: 2D8A1 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66390-1-PBS in a different storage buffer formulation.

CD74 Monoclonal antibody, PBS Only

CD74 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 66390-1-PBS

产品说明书

CloneNo. 2D8A1

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

Ia antigen-associated invariant chain, HLA-DR antigens-associated invariant chain, HLADG, DHLAG, Class-II-associated invariant chain peptide

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66390-1-PBS targets CD74 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag25503

Product name: Recombinant human CD74 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-48 aa of BC018726

Sequence: MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGA

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 CD74 molecule, major histocompatibility complex, class II invariant chain
别名 Ia antigen-associated invariant chain, HLA-DR antigens-associated invariant chain, HLADG, DHLAG, Class-II-associated invariant chain peptide
计算分子量 34 kDa
观测分子量 33 kDa
GenBank蛋白编号BC018726
基因名称 CD74
Gene ID (NCBI) 972
RRIDAB_2881766
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP04233
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD74, also known as MHC class II invariant chain Ii or HLA-DR-associated invariant chain, is a non-polymorphic type II transmembrane glycoprotein. CD74 is mainly distributed in B cells, monocytes, Langerhans cells, dendritic cells and thymic epithelial cells, and is also expressed in epithelial cells. CD74 plays a key role in MHC class II antigen processing and also serves as a cell surface receptor for the macrophage cytokine MIF. CD74 plays an important role in cardiovascular diseases such as atherosclerosis, ischemic heart disease, and myocardial hypertrophy.(PMID: 15475450; PMID: 27752708; PMID: 38992165;PMID: 36712241).

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