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验证数据展示

  • WB analysis of human spleen using 60350-1-Ig (same clone as 60350-1-PBS)

    WB analysis of human spleen using 60350-1-Ig (same clone as 60350-1-PBS)

    human spleen tissue were subjected to SDS PAGE followed by western blot with 60350-1-Ig (CD41/Integrin alpha 2b Antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60350-1-PBS in a different storage buffer formulation.

CD41 Monoclonal antibody, PBS Only

CD41 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 60350-1-PBS

产品说明书

CloneNo. 6D7C5

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, Indirect ELISA

别名

CD41a, 6D7C5, CD41B, GP2B, GPalpha IIb

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

60350-1-PBS targets CD41 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
别名 CD41a, 6D7C5, CD41B, GP2B, GPalpha IIb
计算分子量 113 kDa
观测分子量 125 kDa
GenBank蛋白编号BC126442
基因名称 CD41
Gene ID (NCBI) 3674
RRIDAB_2881459
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDP08514
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.