验证数据展示
经过测试的应用
Positive FC detected in | mouse peripheral blood platelets |
推荐稀释比
应用 | 推荐稀释比 |
---|---|
Flow Cytometry (FC) | FC : 0.5 ug per 10^6 cells in 100 μl suspension |
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
发表文章中的应用
FC | See 1 publications below |
产品信息
FITC-65189 targets CD41 in FC applications and shows reactivity with mouse samples.
经测试应用 | FC Application Description |
文献引用应用 | FC |
经测试反应性 | mouse |
免疫原 | Mouse platelets 种属同源性预测 |
宿主/亚型 | Rat / IgG1, kappa |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | integrin alpha 2b |
别名 | Itga2b, GpIIb, integrin alpha 2b, MWReg30 |
GenBank蛋白编号 | BC120493 |
基因名称 | CD41 |
Gene ID (NCBI) | 16399 |
RRID | AB_3085000 |
偶联类型 | FITC Plus Fluorescent Dye |
最大激发/发射波长 | 495 nm / 524 nm |
形式 | Liquid |
纯化方式 | Affinity purification |
UNIPROT ID | Q9QUM0 |
储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.
实验方案
Product Specific Protocols | |
---|---|
FC protocol for FITC Plus CD41 antibody FITC-65189 | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |