CoraLite® Plus 405 Anti-Mouse CD41 (MWReg30)

CD41 Monoclonal Antibody for FC
Cat No. CL405-65189

产品说明书

CloneNo. MWReg30

宿主/亚型

Rat / IgG1, kappa

种属反应性

mouse

应用

FC

Itga2b, GpIIb, integrin alpha 2b, MWReg30

缓冲液配方:  PBS and Azide
PBS and Azide
规格价格库存


经过测试的应用

Positive FC detected inmouse peripheral blood platelets, mouse splenocytes
For other applications, we recommend the unconjugated version of this antibody, 65189-1-Ig

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC)FC : 0.5 ug per 10^6 cells in 100 μl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL405-65189 targets CD41 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Mouse platelets 种属同源性预测
宿主/亚型 Rat / IgG1, kappa
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin alpha 2b
别名 Itga2b, GpIIb, integrin alpha 2b, MWReg30
GenBank蛋白编号BC120493
基因名称 CD41
Gene ID (NCBI) 16399
RRIDAB_3083839
偶联类型 CoraLite® Plus 405 Fluorescent Dye
最大激发/发射波长399 nm / 422 nm
形式Liquid
纯化方式Affinity purification
UNIPROT IDQ9QUM0
储存缓冲液 PBS with 0.09% sodium azide, pH 7.3.
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.

实验方案

Product Specific Protocols
FC protocol for CL Plus 405 CD41 antibody CL405-65189Download protocol
Standard Protocols
Click here to view our Standard Protocols
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