验证数据展示
产品信息
83884-3-PBS targets CD40L/CD154 in WB, ELISA applications and shows reactivity with mouse samples.
经测试应用 | WB, ELISA Application Description |
经测试反应性 | mouse |
免疫原 | CD40L/CD154 fusion protein Eg0990 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | CD40 ligand |
别名 | CD154, Cd40l, 240743F5, CD40 ligand, Cd40lg |
计算分子量 | 29 kDa |
观测分子量 | 32 kDa |
GenBank蛋白编号 | NM_011616.2 |
基因名称 | CD154 |
Gene ID (NCBI) | 21947 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | P27548 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The CD40 ligand (CD40L, TRAP, CD154), a member of the TNF superfamily of ligands, is expressed as either a 33 kDa transmembrane homologue or an 18 kDa soluble form (sCD154). CD40L is primarily expressed on activated CD4+ T cells and a small proportion of CD8+ T cells and platelets. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. The CD40/CD40L system is also involved in tumorigenesis.