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验证数据展示

  • FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD244 Rabbit Recombinant Antibody (98133-1-RR, Clone: 241260G10) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98133-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD244 Rabbit Recombinant Antibody (98133-1-RR, Clone:241260G10) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98133-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98133-1-RR

    Affinity and Kinetic Characterization of 98133-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98133-1-RR against Human CD244 were performed. The affinity constant is 1.29 nM.

Anti-Human CD244 Rabbit Recombinant Antibody, PBS Only

CD244 Uni-rAb® Recombinant Antibody for FC
Cat No. 98133-1-PBS

产品说明书

CloneNo. 241260G10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

SLAMF4, 241260G10, 2B4, h2B4, NAIL

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98133-1-PBS targets CD244 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原

CatNo: Eg32087

Product name: Recombinant Human CD244 protein (Myc Tag, His Tag)

Source: mammalian cells-derived, pHZ-KIsec

Tag: Myc & 6*His

Domain: 22-221 aa of BC053985

Sequence: CQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD244 molecule, natural killer cell receptor 2B4
别名 SLAMF4, 241260G10, 2B4, h2B4, NAIL
计算分子量 365 aa, 41 kDa
GenBank蛋白编号BC053985
基因名称 CD244
Gene ID (NCBI) 51744
RRIDAB_3672279
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9BZW8
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs (PMID: 9841922; 30546369). CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs) (PMID: 30546369). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function (PMID: 9841922; 18523281).

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