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验证数据展示

  • WB analysis using 24374-1-AP (same clone as 24374-1-PBS)

    WB analysis using 24374-1-AP (same clone as 24374-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24374-1-AP (CD21 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

    IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 24374-1-AP (CD21 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

    IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 24374-1-AP (CD21 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

CD21 Polyclonal antibody, PBS Only

CD21 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 24374-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

C3DR, Complement C3d receptor, Complement receptor type 2, CR2, EBV receptor

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

24374-1-PBS targets CD21 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag18058

Product name: Recombinant human CR2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 581-930 aa of BC136394

Sequence: QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 complement component (3d/Epstein Barr virus) receptor 2
别名 C3DR, Complement C3d receptor, Complement receptor type 2, CR2, EBV receptor
计算分子量 1092 aa, 119 kDa
观测分子量145 kDa
GenBank蛋白编号BC136394
基因名称 CD21
Gene ID (NCBI) 1380
ENSEMBL Gene IDENSG00000117322
RRIDAB_2879512
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP20023
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD21, also known as complement receptor type 2 (CR2), complement C3d receptor, and Epstein-Barr virus receptor, is a transmembrane protein that contains a small cytoplasmic domain, a transmembrane region and an extracellular domain consisting of 15 tandem short consensus repeat sequences (PMID: 6230668; 2551147). It is expressed on B cells, follicular dendritic cells, thymocytes and a subset of peripheral T cells (PMID: 26119182). CD21 binds complement fragments C3d, C3dg and iC3b and acts as a receptor for the Epstein-Barr virus (PMID: 7753047). On B cells, together with CD19 and CD81, CD21 forms a complex that functions as a co-receptor to the BCR (PMID: 7542009). It is involved in B cells activation and functions.

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