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验证数据展示

  • IHC staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    IHC staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55427-1-AP (CD169 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55427-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    IHC staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55427-1-AP (CD169 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55427-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    IF Staining of human tonsillitis using 55427-1-AP (same clone as 55427-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using CD169 antibody (55427-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55427-1-PBS in a different storage buffer formulation.

CD169 Polyclonal antibody, PBS Only

CD169 Polyclonal Antibody for IHC, IF-P, Indirect ELISA
Cat No. 55427-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IF-P, Indirect ELISA

别名

SIGLEC1, Sialoadhesin, Sialoadhesin/CD169, SIGLEC 1, SN

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

55427-1-PBS targets CD169 in IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sialic acid binding Ig-like lectin 1, sialoadhesin
别名 SIGLEC1, Sialoadhesin, Sialoadhesin/CD169, SIGLEC 1, SN
计算分子量 183 kDa
GenBank蛋白编号NM_023068
基因名称 CD169
Gene ID (NCBI) 6614
RRIDAB_2881327
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BZZ2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD169, also known as sheep erythrocyte receptor (SER), Sialoadhesin (Sn) or Siglec-1, is a sialic acid-binding immunoglobulin-like lectin that belongs to the SIGLEC family of the Ig superfamily (PMID: 3783087; 11133773). CD169 is a single-pass transmembrane protein containing a long extracellular domain, a transmembrane region, and a short cytoplasmic tail (PMID: 11133773). It is primarily expressed on the surface of specific macrophage subsets and its precursor monocytes, as well as on some DCs (PMID: 33408860). CD169 binds to sialic acid-containing glycoconjugates, particularly those with α(2,3)-linkages. It is involved in immune regulation, pathogen recognition, and cell-cell interactions.

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