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验证数据展示

  • WB analysis of HeLa using 66611-1-Ig (same clone as 66611-1-PBS)

    WB analysis of HeLa using 66611-1-Ig (same clone as 66611-1-PBS)

    HeLa cells and A431 cells were subjected to SDS PAGE followed by western blot with 66611-1-Ig (CCRL2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66611-1-Ig (CCRL2 antibody) at dilution of 1:800 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66611-1-Ig (CCRL2 antibody) at dilution of 1:800 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

CCRL2 Monoclonal antibody, PBS Only

CCRL2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66611-1-PBS

产品说明书

CloneNo. 2C1E11

宿主/亚型

Mouse / IgG1

种属反应性

Human

应用

WB, IHC, Indirect ELISA

别名

C C chemokine receptor like 2, CCR11, CCR6, CCRL2, Chemokine receptor CCR11, Chemokine receptor X, CKRX, CRAM, CRAM A, CRAM B, HCR

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66611-1-PBS targets CCRL2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human
免疫原

CatNo: Ag4045

Product name: Recombinant human CCRL2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 250-344 aa of BC025717

Sequence: MWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 chemokine (C-C motif) receptor-like 2
别名 C C chemokine receptor like 2, CCR11, CCR6, CCRL2, Chemokine receptor CCR11, Chemokine receptor X, CKRX, CRAM, CRAM A, CRAM B, HCR
计算分子量 344 aa, 40 kDa
观测分子量 47 kDa
GenBank蛋白编号BC025717
基因名称 CCRL2
Gene ID (NCBI) 9034
RRIDAB_2881971
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDO00421
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Chemokine CC motif receptor-like 2 (CCRL2) is a seven-transmembrane domain receptor that shares structural and functional similarities with the family of atypical chemokine receptors (ACKRs) (PMID: 28743719). CCRL2 does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. CCRL2 has been found on almost all hemopoietic cells, including monocytes, macrophages, polymorphonuclear neutrophils (PMNs), T cells, dendritic cells, natural killer cells, and CD34+ progenitor cells, with PMNs expressing the highest levels (PMID: 15188357). CCRL2 is also expressed by barrier cells, such as lymphatic and blood endothelial cells and bronchial and intestinal epithelial cells (PMID: 29056935).

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