验证数据展示
产品信息
98745-1-PBS targets CCR4 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human |
| 免疫原 |
unknow 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | chemokine (C-C motif) receptor 4 |
| 别名 | C C chemokine receptor type 4, C C CKR 4, CC CKR 4, CCR 4, CD194 |
| 基因名称 | CCR4 |
| Gene ID (NCBI) | 1233 |
| RRID | AB_3746312 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P51679 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CC chemokine receptor 4 (CCR4) is important for regulating immune balance and is known to be expressed selectively on Th2 cells and Treg cells. Expression of CCR4 by tumor cells is associated with skin involvement, but CCR4 also has an important role in normal and tumor immunity (PMID: 16952304). CCR4+ adult T-cell leukemia/lymphoma is an example of the former phenomenon, and Hodgkin lymphoma of the latter, for which an almost identical immunopathogenesis has been reported in many types of cancer (PMID: 21044233, 12485447).
