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CCDC88A-Specific Polyclonal antibody

CCDC88A-Specific Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA

Conjugate

Unconjugated

Cat No : 20060-1-AP

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Synonyms

Akt phosphorylation enhancer, APE, CCDC88A, Girders of actin filament, GIRDIN, GIV, GRDN, HkRP1, Hook related protein 1, KIAA1212

验证数据展示

产品信息

20060-1-AP targets CCDC88A-Specific in ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications ELISA
Tested Reactivity human, mouse, rat
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name coiled-coil domain containing 88A
Synonyms Akt phosphorylation enhancer, APE, CCDC88A, Girders of actin filament, GIRDIN, GIV, GRDN, HkRP1, Hook related protein 1, KIAA1212
Calculated Molecular Weight 216 kDa
GenBank Accession NumberNM_001135597
Gene Symbol CCDC88A
Gene ID (NCBI) 55704
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ3V6T2
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CCDC88A, also named as APE, GRDN and KIAA1212, belongs to the CCDC88 family. CCDC88A enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby it induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation CCDC88A is essential for the integrity of the actin cytoskeleton and for cell migration. It is required for formation of actin stress fibers and lamellipodia. It may be involved in membrane sorting in the early endosome. The antibody is specific to CCDC88A.