CCBL1/KAT1 Polyclonal antibody

CCBL1/KAT1 Polyclonal Antibody for IF/ICC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IF/ICC, WB, ELISA and More (1)

Conjugate

Unconjugated

Cat No : 12156-1-AP

Print datasheet

Synonyms

CCBL1, CCBL1/KAT1, Glutamine transaminase K, GTK, KAT1, KATI, KYAT1, Kynurenine aminotransferase I



经过测试的应用

Positive WB detected inmouse kidney tissue, HeLa cells, L02 cells
Positive IF detected inHeLa cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

12156-1-AP targets CCBL1/KAT1 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IF/ICC, WB, ELISA
Cited ApplicationsWB, IHC
Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Immunogen CCBL1/KAT1 fusion protein Ag2828 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name cysteine conjugate-beta lyase, cytoplasmic
Synonyms CCBL1, CCBL1/KAT1, Glutamine transaminase K, GTK, KAT1, KATI, KYAT1, Kynurenine aminotransferase I
Calculated Molecular Weight 48 kDa
Observed Molecular Weight 48-50 kDa
GenBank Accession NumberBC013069
Gene Symbol CCBL1
Gene ID (NCBI) 883
RRIDAB_10666849
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ16773
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CCBL1 encodes kynurenine aminotransferase 1 (KAT1), a key enzyme involved in kynurenine pathway. CCBL1 catalyzes the production of kynurenic acid, a powerful endogenous excitatory amino acid receptor antagonist that is widely regarded as the potent neuroprotective agent.

实验方案

Product Specific Protocols
WB protocol for CCBL1/KAT1 antibody 12156-1-APDownload protocol
IF protocol for CCBL1/KAT1 antibody 12156-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

Cell

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Authors - Leandro Z Agudelo
humanWB,IHC

J Intern Med

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.

Authors - R Baumgartner
mouseWB

Brain Behav Immun

Kynurenine pathway is altered in BDNF Val66Met knock-in mice: Effect of physical exercise.

Authors - Alessandro Ieraci

Am J Physiol Cell Physiol

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Authors - Maja Schlittler
mouseWB

Sci Rep

Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle.

Authors - Chongye Fang
humanWB

Exp Gerontol

Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.

Authors - V L Wyckelsma