验证数据展示
产品信息
67885-1-PBS targets CBFB in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, FC (Intra), Indirect ELISA Application Description |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Ag31183 Product name: Recombinant human CBFB protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-182 aa of BC018509 Sequence: MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | core-binding factor, beta subunit |
| 别名 | 1D7F2, CBF beta, CBF-beta, Core-binding factor subunit beta, PEA2-beta |
| 计算分子量 | 182 aa, 22 kDa |
| 观测分子量 | 22 kDa |
| GenBank蛋白编号 | BC018509 |
| 基因名称 | CBFB |
| Gene ID (NCBI) | 865 |
| RRID | AB_2918642 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q13951 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CBFB (core binding factor subunit β), forms the heterodimeric complex core-binding factor (CBF). As a critical transcription factor, CBFB is frequently mutated in breast cancer and considered to be of significance in the pathogenesis of cancer.(PMID: 29932212) The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters.) It has calculated molecular weight around 22kDa.
