验证数据展示
产品信息
28092-1-PBS targets CACNA1H in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag26094 Product name: Recombinant human CACNA1H protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1181-1280 aa of NM_001005407 Sequence: MDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQ 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | calcium channel, voltage-dependent, T type, alpha 1H subunit |
| 别名 | CACNA1HB, Cav3.2, EIG6, FLJ90484, Low-voltage-activated calcium channel alpha1 3.2 subunit |
| 计算分子量 | 259 kDa |
| 观测分子量 | 259 kDa |
| GenBank蛋白编号 | NM_001005407 |
| 基因名称 | CACNA1H |
| Gene ID (NCBI) | 8912 |
| RRID | AB_3742275 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O95180 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) is located in the plasma membrane of various tissues, including the brain cortex, amygdala, caudate nucleus, putamen, kidney, liver, and heart. This subunit regulates muscle contraction, secretion, neurotransmission, and gene expression by forming the pore (PMID: 33985586). Predominantly, the changes observed are missense mutations associated with gain-of-function, resulting in an increased influx of calcium into adrenal cells (PMID: 33985586; 37311830).
