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验证数据展示

  • WB analysis using 26213-1-AP (same clone as 26213-1-PBS)

    WB analysis using 26213-1-AP (same clone as 26213-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26213-1-AP (C9orf82 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • IP experiment of A431 using 26213-1-AP (same clone as 26213-1-PBS)

    IP experiment of A431 using 26213-1-AP (same clone as 26213-1-PBS)

    IP result of anti-C9orf82 (IP:26213-1-AP, 4ug; Detection:26213-1-AP 1:3000) with A431 cells lysate 800 ug. This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 26213-1-AP (CAAP1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 26213-1-AP (CAAP1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

CAAP1 Polyclonal antibody, PBS Only

CAAP1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 26213-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

C9orf82, CAAP, Caspase activity and apoptosis inhibitor 1, Conserved anti-apoptotic protein, RP11 337A23.1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

26213-1-PBS targets CAAP1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag23850

Product name: Recombinant human C9orf82 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-361 aa of BC014658

Sequence: MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRSTDSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSKKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 9 open reading frame 82
别名 C9orf82, CAAP, Caspase activity and apoptosis inhibitor 1, Conserved anti-apoptotic protein, RP11 337A23.1
观测分子量47-55 kDa
GenBank蛋白编号BC014658
基因名称 C9orf82
Gene ID (NCBI) 79886
RRIDAB_3742173
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H8G2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CAAP1 (Caspase Activity and Apoptosis Inhibitor 1), also known as C9orf82, is an evolutionarily conserved anti-apoptotic protein. It inhibits apoptosis by interfering with the activation of caspase-10, thereby blocking the feedback amplification loop of caspase-3/9 in the mitochondrial apoptotic pathway. Recent studies have revealed that CAAP1 plays a dual role in the regulation of autophagy, balancing the processes of autophagy and apoptosis. In tumor biology, the expression level of CAAP1 is associated with chemotherapy resistance in various cancers, making it a potential prognostic biomarker. In addition, CAAP1 is involved in neuroprotective mechanisms and plays an important role in hypoxic-ischemic brain injury by regulating neuronal apoptosis. Its expression is finely regulated by non-coding RNA networks, including MKL1/miR-5100 and miR-184-5p. (PMID: 30629682)

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