• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Bax inhibitor peptide V5 acetate

CAS号

分子式

C29H54N6O8S

主要靶点

Apoptosis

仅限科研使用

Cat No : CM13647

Print datasheet

Synonyms

Apoptosis|579492-81-2|579492-81-2 free base|Bax inhibitor peptide V5 acetate|Bax inhibitor peptide V5 Acetate|Bax inhibitor peptide V-5 acetate|Bax inhibitor peptide V5 acetate(579492-81-2 free base)

验证数据展示

  • CAS No.:

    Bax inhibitor peptide V5 acetate
    CAS#:

产品信息

CAS号
分子式 C29H54N6O8S
主要靶点 Apoptosis
主要通路 凋亡
分子量 646.85
纯度 99.2%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Apoptosis|579492-81-2|579492-81-2 free base|Bax inhibitor peptide V5 acetate|Bax inhibitor peptide V5 Acetate|Bax inhibitor peptide V-5 acetate|Bax inhibitor peptide V5 acetate(579492-81-2 free base)

体内活性

Bax inhibitor peptide V5（BIP-V5；100μM）显著提高了分离后的胰岛功能，并在小鼠模型中改善了胰岛移植后的移植物功能[2]。

体外活性

Bax inhibitor peptide V5（BIP-V5；0-50 μM）降低STF-cMyc细胞的死亡率，但对SW620或NCI-H23细胞无效。[1]。Bax inhibitor peptide V5 处理可上调抗凋亡蛋白 Bcl-2 和 XIAP 的表达，上调幅度分别超过 3 倍和 11 倍，下调凋亡诱导蛋白 Bax、Bad 和核因子-κB-p65 的表达，下调幅度分别为 10%、30% 和近 50%[2]。

溶解度

DMSO:100 mg/mL (154.6 mM);Saline:100 mg/mL (154.6 mM);H2O:100 mg/mL (170.42 mM)

参考文献

1.Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65.
2.Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2