验证数据展示
产品信息
85614-4-PBS targets BST2 in WB, Indirect ELISA applications and shows reactivity with mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | mouse |
| 免疫原 |
CatNo: Eg2669 Product name: Recombinant Mouse Bst2 protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 52-152 aa of NM_198095.2 Sequence: TANSVACRDGLRAQAECRNTTHLLQRQLTRTQDSLLQAETQANSCNLTVVTLQESLEKKVSQALEQQARIKELENEVTKLNQELENLRIQKETSSTVQVNS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | bone marrow stromal cell antigen 2 |
| 别名 | Bone marrow stromal antigen 2, BST-2, CD317, HM1.24 antigen |
| 计算分子量 | 19 kDa |
| 观测分子量 | 30-36 kDa |
| GenBank蛋白编号 | NM_198095.2 |
| 基因名称 | Bst2 |
| Gene ID (NCBI) | 69550 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8R2Q8 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection. Observed MW of BST2 is 30-36 kDa (PMID: 19196977; 21237475).