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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85063-4-RR

    Affinity and Kinetic Characterization of 85063-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85063-4-RR against Human BAG2 were performed. The affinity constant is 0.644 nM.

BAG2 Recombinant antibody, PBS Only

BAG2 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85063-4-PBS

产品说明书

CloneNo. 242717G4

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

242717G4, BAG-2, KIAA0576

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy BAG2 Ready-To-Use IHC Kit. BAG2 primary antibody included.

产品信息

85063-4-PBS targets BAG2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 BAG2 fusion protein Ag30873 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 BCL2-associated athanogene 2
别名 242717G4, BAG-2, KIAA0576
计算分子量 24 kDa
观测分子量25 kDa
GenBank蛋白编号NM_004282
基因名称 BAG2
Gene ID (NCBI) 9532
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO95816
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BAG2 (BAG family molecular chaperone regulator 2) is one of six proteins in mammals that contain the BAG domain, which belongs to the BAG (Bcl-2-associated athanogene) family. BAG2 has been described as a negative regulator of the chaperone-associated ubiquitin ligase C terminus of Hsc70-interacting protein (CHIP) that participates in the ubiquitin-mediated proteasomal degradation of misfolded substrate proteins (PMID: 16207813). BAG2 is widely expressed in human tissues, including brown adipose, heart and lung tissue, as well as in various types of tumor cells, including renal cell carcinoma, glioblastoma and thyroid carcinoma cells (PMID: 28536620). BAG2 overexpression is associated with poor prognosis in patients and mutp53 accumulation in tumors (PMID: 26271008).