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Atg4B-IN-2

CAS号

2765008-88-4

分子式

C21H30O3

主要靶点

Others

仅限科研使用

Cat No : CM20930

Print datasheet

Synonyms

PLA2|ATG4B|Autophagy

验证数据展示

  • CAS No.: 2765008-88-4

    Atg4B-IN-2
    CAS#: 2765008-88-4

产品信息

CAS号 2765008-88-4
分子式 C21H30O3
主要靶点 Others
主要通路 代谢|自噬
分子量 330.46
纯度 98.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Shipping with blue ice.
别名 PLA2|ATG4B|Autophagy

靶点活性

Atg4B:3.1 μM (Ki)|Atg4B:11 μM|PLA2:3.5 μM

体外活性

Atg4B-IN-2（1-10μM；2小时）能够在氨基酸缺乏（AF）条件下处理的细胞中恢复p62表达[1]。在1和5μM浓度（2小时）下，Atg4B-IN-2在1μM时中度降低自噬囊泡的数目，并在5μM时几乎完全抑制自噬[1]。在5μM浓度（2小时）下，Atg4B-IN-2抑制Abi诱导的自噬，显著增强细胞凋亡，并提高对Abi的敏感性[1]。

溶解度

DMSO:80 mg/mL (242.09 mM)

参考文献

1.Kudo Y, Endo S, Fujita M, et al. Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2022;65(6):4878-4892.

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