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验证数据展示

  • WB analysis using 85067-5-RR (same clone as 85067-5-PBS)

    WB analysis using 85067-5-RR (same clone as 85067-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85067-5-RR (ARR3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85067-5-PBS in a different storage buffer formulation.

  • IF Staining of mouse eye using 85067-5-RR (same clone as 85067-5-PBS)

    IF Staining of mouse eye using 85067-5-RR (same clone as 85067-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse eye tissue using Arrestin C antibody (85067-5-RR, Clone: 242751B12 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85067-5-PBS in a different storage buffer formulation.

  • IF Staining of mouse eye using 85067-5-RR (same clone as 85067-5-PBS)

    IF Staining of mouse eye using 85067-5-RR (same clone as 85067-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse eye tissue using Arrestin C antibody (85067-5-RR, Clone: 242751B12 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85067-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85067-5-RR

    Affinity and Kinetic Characterization of 85067-5-RR

    Biolayer interferometry (BLl) kinetic assays of 85067-5-RR against Human Arrestin C were performed. The affinity constant is below 1 pM.

Arrestin C Recombinant antibody, PBS Only

Arrestin C Uni-rAbTM Recombinant Antibody for WB, IF-P, Indirect ELISA
Cat No. 85067-5-PBS

产品说明书

CloneNo. 242751B12

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF-P, Indirect ELISA

别名

Arrestin-C, ARR3, C-arrestin, CAR, ARRX

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85067-5-PBS targets Arrestin C in WB, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 Arrestin C fusion protein Ag1580 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 arrestin 3, retinal (X-arrestin)
别名 Arrestin-C, ARR3, C-arrestin, CAR, ARRX
计算分子量 43 kDa
观测分子量47-50 kDa
GenBank蛋白编号BC012096
基因名称 Arrestin C
Gene ID (NCBI) 407
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP36575
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Arrestin C, also known as Arrestin 3 or Retinal Cone Arrestin, is a protein encoded by the ARR3 gene. It belongs to the arrestin family, which plays a crucial role in regulating G-protein-coupled receptor (GPCR) signaling and trafficking. Arrestin C is composed of two major domains: the N-domain and the C-domain, connected by a hinge region. These domains form a structure resembling two clamshells placed end-to-end. The C-terminal tail (C-tail) of Arrestin C interacts extensively with the N-domain, stabilizing its basal conformation. Arrestin C is predominantly expressed in cone photoreceptors and pinealocytes in the retina. It is involved in the shut-off mechanisms associated with high-acuity color vision by binding to phosphorylated and activated opsins, thereby inhibiting their ability to interact with transducin.