• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

AZD 3147

CAS号

1101810-02-9

分子式

C24H31N5O4S2

主要靶点

mTOR

仅限科研使用

Cat No : CM10486

Print datasheet

Synonyms

AZD3147|AZD-3147|AZD 3147|mTORC2|mTORC1

验证数据展示

  • CAS No.: 1101810-02-9

    AZD 3147
    CAS#: 1101810-02-9

产品信息

CAS号 1101810-02-9
分子式 C24H31N5O4S2
主要靶点 mTOR
主要通路 PI3K/Akt/mTOR 信号通路
分子量 517.66
纯度 98.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 AZD3147|AZD-3147|AZD 3147|mTORC2|mTORC1

体内活性

AZD3147在小鼠体内表现出的药代动力学参数包括清除率（CL）为78 mL/min/kg，稳态分布体积（Vss）为2.3 L/kg，半衰期（t1/2）为0.9小时，以及生物利用度（F）为61%[1]。

体外活性

在NIH3T3细胞中，AZD3147（1.5-50 nM）减轻了FGF介导的纤毛伸展[2]。AZD3147抑制神经母细胞瘤细胞系Kelly（IC50 = 0.88 nM）和IMR-32（IC50 = 662.4 nM）的细胞活力[3]。

溶解度

Hydrochloride acid:100 mg/mL (193.18 mM);Ethanol:1 mg/mL (1.93 mM);DMSO:46.8 mg/mL (90.41 mM)

参考文献

1.Pike, K.G., Morris, J., Ruston, L., et al. Discovery of AZD3147: A potent, selective dual inhibitor of mTORC1 and mTORC2. J. Med. Chem. 58(5), 2326-2349 (2015). AZD 3147
2.Michaela Kunova Bosakova, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018 Mar 15;27(6):1093-1105.
3.Rebecca Waetzig, et al. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci. 2021 Jan 1;18(1):137-149.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2