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AZ-Dyrk1B-33

CAS号

1679330-37-0

分子式

C19H16N4

主要靶点

DYRK

仅限科研使用

Cat No : CM11616

Print datasheet

Synonyms

osteosarcoma|response|resistance|kinase|Inhibitor|mechanism|metabolic|Minibrain-related|Mirk-related|undergoing|stress|syndrome|AZ Dyrk1B 33|AZDyrk1B33|AZ-Dyrk-1B-33|AZ-Dyrk1B-33|cells|3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine|inhibit|DYRK|Dyrk pS421|Dyrk1B|Dual specificity tyrosine regulated kinase|Dual specificity tyrosine phosphorylation regulated kinase

验证数据展示

  • CAS No.: 1679330-37-0

    AZ-Dyrk1B-33
    CAS#: 1679330-37-0

产品信息

CAS号 1679330-37-0
分子式 C19H16N4
主要靶点 DYRK
主要通路 细胞周期|蛋白酪氨酸激酶
分子量 300.36
纯度 99.99%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 osteosarcoma|response|resistance|kinase|Inhibitor|mechanism|metabolic|Minibrain-related|Mirk-related|undergoing|stress|syndrome|AZ Dyrk1B 33|AZDyrk1B33|AZ-Dyrk-1B-33|AZ-Dyrk1B-33|cells|3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine|inhibit|DYRK|Dyrk pS421|Dyrk1B|Dual specificity tyrosine regulated kinase|Dual specificity tyrosine phosphorylation regulated kinase

靶点活性

DYRK1B:7 nM|DYRK (pS421):0.192 μM

体外活性

给予AZ-Dyrk1B-33后可观察到在细胞内抑制Dyrk pS421的磷酸化作用，其半抑制浓度（IC50）为0.192 μM，并且对敏感性没有影响[1]。

溶解度

DMSO:120 mg/mL (399.52 mM)

参考文献

1.Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

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