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验证数据展示

  • WB analysis using 55375-1-AP (same clone as 55375-1-PBS)

    WB analysis using 55375-1-AP (same clone as 55375-1-PBS)

    Unboiled mouse lung tissue were subjected to SDS PAGE followed by western blot with 55375-1-AP (ATP7A-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55375-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse lung using 55375-1-AP (same clone as 55375-1-PBS)

    IP experiment of mouse lung using 55375-1-AP (same clone as 55375-1-PBS)

    IP result of anti-ATP7A-Specific (IP:55375-1-AP, 4ug; Detection:55375-1-AP 1:500) with mouse lung tissue lysate 1520 ug. This data was developed using the same antibody clone with 55375-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 55375-1-AP (same clone as 55375-1-PBS)

    IHC staining of human lung cancer using 55375-1-AP (same clone as 55375-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 55375-1-AP (ATP7A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55375-1-PBS in a different storage buffer formulation.

ATP7A-Specific Polyclonal antibody, PBS Only

ATP7A-Specific Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 55375-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

ATP7A, ATPase, Cu++ transporting, alpha polypeptide, Copper transporting ATPase 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

55375-1-PBS targets ATP7A-Specific in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ATPase, Cu++ transporting, alpha polypeptide
别名 ATP7A, ATPase, Cu++ transporting, alpha polypeptide, Copper transporting ATPase 1
计算分子量 165 kDa
观测分子量 170 kDa
GenBank蛋白编号NM_000052
基因名称 ATP7A
Gene ID (NCBI) 538
RRIDAB_3743207
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ04656
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ATPase copper transporting alpha(ATP7A) is a type of transmembrane P-type ATPase for copper transport. ATP7A and ATP7B are homologous genes responsible for copper transport across cell membranes. ATP7A transports copper ions from the Golgi membrane to copper-dependent enzymes (such as dopamine β-hydroxylase) in the secretory pathway. When copper ion concentrations rise, ATP7A relocalizes from the Golgi apparatus to the plasma membrane, promoting copper efflux and thereby protecting cells from copper toxicity. Mutations in ATP7A are associated with Menkes disease (MNK)( PMID: 28389643, 30341172).

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