验证数据展示
产品信息
83827-3-PBS targets ATP2B1 in WB, IHC, Cytometric bead array, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, IHC, Cytometric bead array, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | ATP2B1 fusion protein Ag32423 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | ATPase, Ca++ transporting, plasma membrane 1 |
别名 | 240848D10, PMCA1, PMCA1kb |
计算分子量 | 135 kDa |
观测分子量 | 130 kDa |
GenBank蛋白编号 | NM_001001323.1 |
基因名称 | ATP2B1 |
Gene ID (NCBI) | 490 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P20020 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ATPase plasma membrane Ca2+ transporting 1 (ATP2B1, also known as plasma membrane Ca2+ pump isoform 1; PMCA1) belongs to the family of ATP-driven calmodulin-dependent Ca2+ pumps that participate in the regulation of intracellular free Ca2+ (PMID:35358416). The ATP2B1 contents of extracellular vesicles are increased in prostate cancer treated with enzalutamide and are negatively regulated by androgen receptors (PMID:29105980). ATP2B1 plays an important role in the prognosis of cholangiocarcinoma. Furthermore, ATP2B1 plays an important role in the prognosis of cholangiocarcinoma and can be a prognostic factor for cholangiocarcinoma (PMID:35875160).