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验证数据展示

  • IF Staining of HeLa using CL488-84798-5

    IF Staining of HeLa using CL488-84798-5

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using CoraLite® Plus 488 ATIC antibody (CL488-84798-5, Clone: 242324C8 ) at dilution of 1:200.

CoraLite® Plus 488-conjugated ATIC Recombinant monoclonal antibody

ATIC Uni-rAb® Recombinant Antibody for IF/ICC
Cat No. CL488-84798-5

产品说明书

CloneNo. 242324C8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC

别名

242324C8, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR, AICAR formyltransferase, AICAR transformylase/inosine monophosphate cyclohydrolase

缓冲液配方:  PBS, Proclin 300, BSA, Glycerol
PBS, Proclin 300, BSA, Glycerol
偶联物:  CoraLite® Plus 488
规格价格库存

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经过测试的应用

Positive IF/ICC detected inHeLa cells
For other applications, we recommend the unconjugated version of this antibody, 84798-5-PBS

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-84798-5 targets ATIC in IF/ICC applications and shows reactivity with human samples.

经测试应用 IF/ICC Application Description
经测试反应性 human
免疫原

CatNo: Ag1052

Product name: Recombinant human ATIC protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 291-592 aa of BC008879

Sequence: DLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
别名 242324C8, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR, AICAR formyltransferase, AICAR transformylase/inosine monophosphate cyclohydrolase
计算分子量 65 kDa
观测分子量62 kDa
GenBank蛋白编号BC008879
基因名称 ATIC
Gene ID (NCBI) 471
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式Liquid
纯化方式Protein A purification
UNIPROT IDP31939
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC, also known as AICAR) is an enzyme that can catalyze the last two reactions in the de novo purine biosynthetic pathway. It has been previously reported to be upregulated and to participate in myeloma and hepatocellular carcinoma progression (PMID: 35251351).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 ATIC antibody CL488-84798-5Download protocol
Standard Protocols
Click here to view our Standard Protocols
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