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验证数据展示

  • IHC staining of mouse colon using 30508-1-AP (same clone as 30508-1-PBS)

    IHC staining of mouse colon using 30508-1-AP (same clone as 30508-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 30508-1-AP (ARHGEF11 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

  • WB analysis using 30508-1-AP (same clone as 30508-1-PBS)

    WB analysis using 30508-1-AP (same clone as 30508-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30508-1-AP (ARHGEF11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293T using 30508-1-AP (same clone as 30508-1-PBS)

    WB analysis of HEK-293T using 30508-1-AP (same clone as 30508-1-PBS)

    WB result of ARHGEF11 antibody (30508-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ARHGEF11 transfected HEK-293T cells. This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ARHGEF11 Polyclonal antibody, PBS Only

ARHGEF11 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 30508-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

GTRAP48, KIAA0380, PDZ RHOGEF

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

30508-1-PBS targets ARHGEF11 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag33104

Product name: Recombinant human ARHGEF11 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1223-1522 aa of

Sequence: ETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Rho guanine nucleotide exchange factor (GEF) 11
别名 GTRAP48, KIAA0380, PDZ RHOGEF
计算分子量168 kDa
观测分子量200-220 kDa
基因名称 ARHGEF11
Gene ID (NCBI) 9826
RRIDAB_3086341
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15085
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ARHGEF11 (Rho guanine nucleotide exchange factor 11) is a specific guanine nucleotide exchange factor (GEF) for RhoA, which is a critical regulator of actin cytoskeleton dynamics and organization of dendritic spines and inhibitor of spine maintenance (PMID: 28036092). ARHGEF11 has been proven to promote tumor metastasis in glioblastoma and ovarian carcinoma (PMID: 33122451).

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