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验证数据展示

  • WB analysis using 17541-1-AP (same clone as 17541-1-PBS)

    WB analysis using 17541-1-AP (same clone as 17541-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17541-1-AP (ARAP1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17541-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 17541-1-AP (same clone as 17541-1-PBS)

    IHC staining of human kidney using 17541-1-AP (same clone as 17541-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17541-1-AP (ARAP1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17541-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 17541-1-AP (same clone as 17541-1-PBS)

    IHC staining of human kidney using 17541-1-AP (same clone as 17541-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17541-1-AP (ARAP1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17541-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 17541-1-AP (same clone as 17541-1-PBS)

    IHC staining of mouse heart using 17541-1-AP (same clone as 17541-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 17541-1-AP (ARAP1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17541-1-PBS in a different storage buffer formulation.

ARAP1 Polyclonal antibody, PBS Only

ARAP1 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 17541-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, ELISA

别名

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, Centaurin-delta-2, CENTD2, Cnt-d2, KIAA0782

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17541-1-PBS targets ARAP1 in WB, IHC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag11597

Product name: Recombinant human ARAP1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 329-679 aa of BC056401

Sequence: LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRMSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
别名 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, Centaurin-delta-2, CENTD2, Cnt-d2, KIAA0782
计算分子量162 kDa
观测分子量180 kDa
GenBank蛋白编号BC056401
基因名称 ARAP1
Gene ID (NCBI) 116985
RRIDAB_3741923
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96P48
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ARAP1 is a member of ARAP family with both Arf GAP and Rho GAP activities, by which ARAP1 makes a direct link between ADP-ribosylation factor (Arf) GTPases and Rho GTPases signaling. ARAP1 is involved in membrane trafficking and receptor recycling. It supports the plasma membrane recycling of the angiotensin II type 1 receptor (AT1) and regulates the cell-specific trafficking of the pro-death receptor TRAIL-R1/DR4, thereby promoting TRAIL-induced apoptosis in certain cell types. (PMID: 14559250, PMID: 18165900, PMID: 38008882)

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