验证数据展示
For other applications, we recommend the unconjugated version of this antibody, 66830-1-Ig
产品信息
CL647-66830 targets APOE in applications and shows reactivity with human, mouse samples.
| 经测试应用 | Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | APOE fusion protein Ag28186 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | Apolipoprotein E |
| 别名 | AD2, Apo E, APOE, apolipoprotein E, LPG |
| 计算分子量 | 36 kDa |
| 观测分子量 | 34-36 kDa |
| GenBank蛋白编号 | BC003557 |
| 基因名称 | APOE |
| Gene ID (NCBI) | 348 |
| 偶联类型 | CoraLite® Plus 647 Fluorescent Dye |
| 最大激发/发射波长 | 654 nm / 674 nm |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P02649 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The apolipoprotein E (APOE) is a 299-amino acid polypeptide that mediates the binding, internalization, and catabolism of lipoprotein particles, and also serve as a ligand for the LDL (APO B/E) receptor and for the specific APOE receptor (chylomicron remnant) of hepatic tissues. The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of APOE isoforms but do not provide mechanistic insight.