验证数据展示
产品信息
25328-1-PBS targets APOB48R in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag18204 Product name: Recombinant human APOB48R protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 851-1088 aa of BC119786 Sequence: SQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQARLGRPKPQ 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | apolipoprotein B48 receptor |
| 别名 | apoB 48R, apoB-48R, APOBR, Apolipoprotein B 100 receptor, Apolipoprotein B 48 receptor |
| 计算分子量 | 1088 aa, 116 kDa |
| 观测分子量 | 116 kDa |
| GenBank蛋白编号 | BC119786 |
| 基因名称 | APOB48R |
| Gene ID (NCBI) | 55911 |
| RRID | AB_3742144 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q0VD83 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Apolipoprotein B48 receptor (APOB48R) is a macrophage receptor that binds to apoB of dietary triglyceride-rich lipoproteins or to a similar apoB-like domain in hypertriglyceridemic very low-density lipoprotein (HTG-VLDL). This receptor is crucial for the uptake of chylomicrons, HTG-VLDL, and trypsinized VLDL lacking apoE in macrophages. APOB48R may contribute necessary lipids, lipid-soluble vitamins, and other nutrients to reticuloendothelial cells. Elevated plasma triglyceride levels may cause APOB48R to be a factor in foam cell formation, endothelial dysfunction, and atherothrombogenesis (PMID: 10852956; 9633939; 15591219).
