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AMG9810

CAS号

545395-94-6

分子式

C21H23NO3

主要靶点

TRP/TRPV Channel

仅限科研使用

Cat No : CM06797

Print datasheet

Synonyms

Inhibitor|TRPV1|TRPChannel|TRPV Channel|TRPVChannel|Transient receptor potential channels|TRP Channel|inhibit|AMG 9810|AMG9810|AMG-9810|(2E)-N-(2,3-二氢-1,4-苯并二噁英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺

验证数据展示

  • CAS No.: 545395-94-6

    AMG9810
    CAS#: 545395-94-6

产品信息

CAS号 545395-94-6
分子式 C21H23NO3
主要靶点 TRP/TRPV Channel
主要通路 离子通道
分子量 337.41
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|TRPV1|TRPChannel|TRPV Channel|TRPVChannel|Transient receptor potential channels|TRP Channel|inhibit|AMG 9810|AMG9810|AMG-9810|(2E)-N-(2,3-二氢-1,4-苯并二噁英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺

靶点活性

TRPV1 (rat):85.6 nM|TRPV1 (human):24.5 nM

体内活性

在通过足底注射完全弗氏佐剂引发的大鼠炎症痛模型中，30-100 mg/kg 的 AMG 9810 能逆转热和机械性高敏感症[3]。

溶解度

DMSO:40 mg/mL (118.55 mM)

参考文献

1.Mcdougle D R , Watson J E , Abdeen A A , et al. Anti-inflammatory ω-3 endocannabinoid epoxides[J]. Proceedings of the National Academy of Sciences, 2017:201610325.
2.Wolf F I , Vsimonacci T . Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.[J]. European Journal of Pharmacology, 2010, 641(2):135-141.
3.Gavva NR, et al. AMG9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84.

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