验证数据展示
产品信息
68237-1-PBS targets ALDH2 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat, Rabbit, Pig samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | Human, Mouse, Rat, Rabbit, Pig |
免疫原 | ALDH2 fusion protein Ag7463 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | aldehyde dehydrogenase 2 family (mitochondrial) |
别名 | ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM |
计算分子量 | 56 kDa |
观测分子量 | 50-55 kDa |
GenBank蛋白编号 | BC002967 |
基因名称 | ALDH2 |
Gene ID (NCBI) | 217 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P05091 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.