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验证数据展示

  • WB analysis of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    WB analysis of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 16479-1-AP (ADO antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16479-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    IHC staining of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain using 16479-1-AP (ADO antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16479-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    IHC staining of human brain using 16479-1-AP (same clone as 16479-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain using 16479-1-AP (ADO antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16479-1-PBS in a different storage buffer formulation.

  • WB analysis using 16479-1-AP (same clone as 16479-1-PBS)

    WB analysis using 16479-1-AP (same clone as 16479-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16479-1-AP (ADO antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16479-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ADO Polyclonal antibody, PBS Only

ADO Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 16479-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

2 aminoethanethiol dioxygenase, 2-aminoethanethiol dioxygenase, C10orf22, Cysteamine dioxygenase, EC:1.13.11.19

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

16479-1-PBS targets ADO in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag9598

Product name: Recombinant human ADO protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-270 aa of BC018660

Sequence: MPRDNMASLIQRIARQACLTFRGSWGGRGASDRDAASGAEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 2-aminoethanethiol (cysteamine) dioxygenase
别名 2 aminoethanethiol dioxygenase, 2-aminoethanethiol dioxygenase, C10orf22, Cysteamine dioxygenase, EC:1.13.11.19
计算分子量 270 aa, 30 kDa
观测分子量 28 kDa-30 kDa
GenBank蛋白编号BC018660
基因名称 ADO
Gene ID (NCBI) 84890
RRIDAB_2222204
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96SZ5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ADO, or 2-aminoethanethiol dioxygenase, cysteamine dioxygenase, is a thiol dioxygenase in humans that adds two oxygen atoms to cysteamine, forming hypotaurine (PMID: 39637922). ADO has been reported to exhibit two distinct biological functions with a nonheme iron center. It catalyzes oxidation of both cysteamine in sulfur metabolism and N-terminal cysteine-containing proteins or peptides, such as regulator of G protein signaling 5 (RGS5) (PMID: 34508780). ADO is ubiquitously expressed with the highest levels in brain, heart, and skeletal muscle. Western blot analysis detected two bands at 28~30 kDa as indicated in publications (PMID: 17581819).

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