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验证数据展示

  • WB analysis using 31756-1-AP (same clone as 31756-1-PBS)

    WB analysis using 31756-1-AP (same clone as 31756-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31756-1-AP (ADGB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31756-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 31756-1-AP (same clone as 31756-1-PBS)

    IHC staining of mouse testis using 31756-1-AP (same clone as 31756-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 31756-1-AP (C6orf103 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31756-1-PBS in a different storage buffer formulation.

  • IHC staining of rat testis using 31756-1-AP (same clone as 31756-1-PBS)

    IHC staining of rat testis using 31756-1-AP (same clone as 31756-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat testis tissue slide using 31756-1-AP (C6orf103 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31756-1-PBS in a different storage buffer formulation.

  • IHC staining of rat testis using 31756-1-AP (same clone as 31756-1-PBS)

    IHC staining of rat testis using 31756-1-AP (same clone as 31756-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat testis tissue slide using 31756-1-AP (C6orf103 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31756-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse testis using 31756-1-AP (same clone as 31756-1-PBS)

    IF Staining of mouse testis using 31756-1-AP (same clone as 31756-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse testis tissue using ADGB antibody (31756-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31756-1-PBS in a different storage buffer formulation.

ADGB Polyclonal antibody, PBS Only

ADGB Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 31756-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF-P, Indirect ELISA

别名

C6orf103, Androglobin, Calpain 7 like protein, Calpain-7-Like Protein, CAPN7L

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

31756-1-PBS targets ADGB in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag36246

Product name: Recombinant human C6orf103 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 550-700 aa of NM_024694

Sequence: ETATHSQTDLSQITKATSQGNTASQVILGKGTDEQTDFGLGDAHQSDGLNLEREIVSQTTATQEKSQEELPTTNNSVSKEIWLDFEDFCVCFQNIYIFHKPSSYCLNFQKSEFKFSEERVSYYLFVDSLKPIELLVCFSALVRWGEYGAL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 6 open reading frame 103
别名 C6orf103, Androglobin, Calpain 7 like protein, Calpain-7-Like Protein, CAPN7L
计算分子量189kDa
观测分子量235 kDa
GenBank蛋白编号NM_024694
基因名称 C6orf103
Gene ID (NCBI) 79747
RRIDAB_3742473
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ8N7X0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ADGB (Androglobin) is an evolutionarily conserved member of the globin protein family. It is specifically and highly expressed in spermatogenic cells (particularly sperm cells) of mammalian testes and in ciliated cells across various tissues. The ADGB protein possesses a unique structure, comprising a globin domain and a calmodulin-binding domain, suggesting its potential role in integrating gas (such as oxygen) sensing with calcium ion signaling functions. Current research indicates that ADGB plays a critical role in spermatogenesis within the male reproductive system, as well as in the formation and functional maintenance of cilia. Its functional deficiency may lead to abnormal sperm morphology and motility defects, thereby affecting male fertility. The target protein ADGB has a size of 235 kDa. This protein is unstable and prone to degradation, with degradation bands observed at 135 kDa, 70 kDa, and 55 kDa. (PMID: 36995441)

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