×
Use Able AI chat for product recommendations

验证数据展示

  • WB analysis using 12302-1-AP (same clone as 12302-1-PBS)

    WB analysis using 12302-1-AP (same clone as 12302-1-PBS)

    mouse skeletal muscle lysates were subjected to SDS PAGE followed by western blot with 12302-1-AP (ACYP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12302-1-PBS in a different storage buffer formulation.

  • IHC staining of human medulloblastoma using 12302-1-AP (same clone as 12302-1-PBS)

    IHC staining of human medulloblastoma using 12302-1-AP (same clone as 12302-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human medulloblastoma using 12302-1-AP (ACYP2 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 12302-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ACYP2 antibody included
  • WB analysis of HepG2 using 12302-1-AP (same clone as 12302-1-PBS)

    WB analysis of HepG2 using 12302-1-AP (same clone as 12302-1-PBS)

    WB result of ACYP2 antibody (12302-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-ACYP2 transfected HepG2 cells. This data was developed using the same antibody clone with 12302-1-PBS in a different storage buffer formulation.

ACYP2 Polyclonal antibody, PBS Only

ACYP2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 12302-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Acylphosphatase-2, ACYM, ACYP, EC:3.6.1.7

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

Planning an IHC experiment? We recommend our IHCeasy ACYP2 Ready-To-Use IHC Kit. ACYP2 primary antibody included.

产品信息

12302-1-PBS targets ACYP2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2948

Product name: Recombinant human ACYP2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-99 aa of BC012290

Sequence: MSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSMKSWLSKVGSPSSRIDRTNFSNEKTISKLEYSNFSIRY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 acylphosphatase 2, muscle type
别名 Acylphosphatase-2, ACYM, ACYP, EC:3.6.1.7
计算分子量 99 aa, 11 kDa
观测分子量 11 kDa
GenBank蛋白编号BC012290
基因名称 ACYP2
Gene ID (NCBI) 98
RRIDAB_10597999
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP14621
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACYP2, also named muscle-type acylphosphatase (ACYM), is a small cytoplasmic hydrolase (EC 3.6.1.7) encoded by the ACYP2 gene at human chromosome 2p16.2, with UniProt ID P14621. It catalyzes hydrolysis of acyl phosphate intermediates of ion pumps, especially sarcoplasmic reticulum Ca²⁺/Mg²⁺-ATPase, regulating intracellular calcium homeostasis and skeletal muscle differentiation. Widely expressed in muscle, brain and tumor tissues, ACYP2 exerts dual oncogenic or tumor-suppressive effects across malignancies. In glioma, it boosts Ca²⁺ efflux to activate c-Myc/STAT3 and drives temozolomide resistance; in hepatocellular carcinoma, it inhibits KCNN4/ERK and TERT to suppress tumor progression. It also participates in glycolysis, cell apoptosis and ion transport, serving as a potential prognostic biomarker for multiple cancers. (PMID: 32517717, 39267048)

||
New chat

Able™

正在加载，请稍候...