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Host
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Species Reactivity
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Species Reactivity
0
Conjugate
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Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    HUVEC cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

ACVRL1 Monoclonal antibody, PBS Only

ACVRL1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66857-1-PBS

产品说明书

CloneNo. 2E11B10

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

2E11B10, Activin receptor like kinase 1, Activin receptor-like kinase 1, ACVRLK1, ALK 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66857-1-PBS targets ACVRL1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag6446

Product name: Recombinant human ACVRL1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 142-503 aa of BC042637

Sequence: HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 activin A receptor type II-like 1
别名 2E11B10, Activin receptor like kinase 1, Activin receptor-like kinase 1, ACVRLK1, ALK 1
计算分子量 56 kDa
观测分子量 56 kDa, 63 kDa
GenBank蛋白编号BC042637
基因名称 ACVRL1
Gene ID (NCBI) 94
RRIDAB_2882196
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDP37023
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.