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验证数据展示

  • IF Staining of PC-3 using CL488-84204-5

    IF Staining of PC-3 using CL488-84204-5

    Immunofluorescent analysis of (4% PFA) fixed PC-3 cells using CoraLite® Plus 488 ABCC5 antibody (CL488-84204-5, Clone: 241380G1 ) at dilution of 1:200.

CoraLite® Plus 488-conjugated ABCC5 Recombinant antibody

ABCC5 Recombinant Antibody for IF/ICC
Cat No. CL488-84204-5

产品说明书

CloneNo. 241380G1

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC

别名

MRP5, 241380G1, ABC33, ABCC 5, ATP-binding cassette sub-family C member 5

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格价格库存

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经过测试的应用

Positive IF/ICC detected inPC-3 cells
For other applications, we recommend the unconjugated version of this antibody, 84204-5-PBS

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-84204-5 targets ABCC5 in IF/ICC applications and shows reactivity with human samples.

经测试应用 IF/ICC Application Description
经测试反应性 human
免疫原 ABCC5 fusion protein Ag31680 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
别名 MRP5, 241380G1, ABC33, ABCC 5, ATP-binding cassette sub-family C member 5
计算分子量 161 kDa
观测分子量161-200 kDa
GenBank蛋白编号NM_005688
基因名称 ABCC5
Gene ID (NCBI) 10057
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式Liquid
纯化方式Protein A purification
UNIPROT IDO15440
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ABCC5, also named MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site are unclear. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 ABCC5 antibody CL488-84204-5Download protocol
Standard Protocols
Click here to view our Standard Protocols