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4-hydroxyphenyl acetate

4-hydroxyphenyl acetate 通过作为 NRF2 稳定剂防止 RPE 氧化应激诱导的坏死。

CAS号

3233-32-7

分子式

C8H8O3

主要靶点

Reductase|Nrf2|Endogenous Metabolite

仅限科研使用

Cat No : CM18291

Print datasheet

Synonyms

NRF2|4 hydroxyphenyl acetate|4hydroxyphenyl acetate|4-hydroxyphenyl Acetate|4-乙酰氧基苯酚

验证数据展示

  • CAS No.: 3233-32-7

    4-hydroxyphenyl acetate
    CAS#: 3233-32-7

产品信息

4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer

CAS号 3233-32-7
分子式 C8H8O3
主要靶点 Reductase|Nrf2|Endogenous Metabolite
主要通路 免疫与炎症
分子量 152.147
纯度 99.80%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 NRF2|4 hydroxyphenyl acetate|4hydroxyphenyl acetate|4-hydroxyphenyl Acetate|4-乙酰氧基苯酚

体外活性

4-AC是一种天然抗氧化剂，表现出强大的保护RPE细胞免受氧化应激引起的坏死能力。从机制上讲，4-AC通过阻断氧化应激引起的细胞ROS增加，并通过稳定及诱导NRF2转录因子的核内转移，上调NQO1和HO-1基因，从而发挥作用。进一步研究显示，NQO1、HO-1和NRF2是4-AC保护RPE细胞免遭tBHP引发死亡所必需的。t2,5-Di-tert-butylhydroquinone，作为NRF2的稳定剂，一致模拟了4-AC对抗tBHP引起的RPE细胞死亡的保护效果[1]。

溶解度

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (13.15 mM);DMSO:30.00 mg/mL (197.18 mM)

参考文献

1.Jakub H , Alexander K , Julia C , et al. 4-Acetoxyphenol Prevents RPE Oxidative Stress–Induced Necrosis by Functioning as an NRF2 Stabilizer[J]. Invest Ophthalmol Vis, 2015, 56(9):5048-5059.
2.Li T , Berberich J , Sahle-Demessie E , et al. A disposable acetylcholine esterase sensor for As( iii ) determination in groundwater matrix based on 4-acetoxyphenol hydrolysis[J]. Analytical Methods, 2019, 11(40):5203-5213.

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