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(-)-Epigallocatechin

(-)-Epigallocatechin is a plant secondary metabolite abundant in green tea, it can prevent conversion of unfolded native polypeptides to amyloid fibrils.

CAS号

970-74-1

分子式

C15H14O7

主要靶点

Telomerase

仅限科研使用

Cat No : CM01130

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Synonyms

EGC;Epigallocatechin;L-Epigallocatechin

验证数据展示

  • CAS No.: 970-74-1

    (-)-Epigallocatechin
    CAS#: 970-74-1

产品信息

(-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. (-)-Epigallocatechin (EGC) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils[3]. The enzyme inhibition study result indicated that epigallocatechin gallate possess strong inhibitory activity on ADA(Adenosine deaminase) [4]. Combined curcumin and EGCG (epigallocatechin gallate) treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Curcumin and EGCG function as antitumor agents for suppressing breast CSCs (cancer stem cell) [5]. In addition, EGCG (Epigallocatechin-3-gallate) exhibited a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The antimicrobial action of EGCG on E. faecalis occurred through the generation of hydroxyl radical[6].

CAS号 970-74-1
分子式 C15H14O7
主要靶点 Telomerase
主要通路 Natural Product
分子量 306.2675
MDL NO MFCD00075939
Pubchem ID 72277
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 EGC;Epigallocatechin;L-Epigallocatechin

溶解度

DMSO149 mg/mL

参考文献

1Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46.
2Wang N, He J, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26
3Wang N, He J, Chang AK, et al. (-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin. J Agric Food Chem. 2015;63(5):1347-1351
4K G A, C S S, J A, C S. Biochemical and computational insights of adenosine deaminase inhibition by Epigallocatechin gallate. Comput Biol Chem. 2019;83:107111
5Chung SS, Vadgama JV. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 2015;35(1):39-46
6Lee P, Tan KS. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015;60(3):393-399

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