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(-)-Epicatechin Gallate

(-)-Epicatechin gallate, a polyphenol, is a apoptosis inducer of tumor cells that found in green tea.

CAS号

1257-08-5

分子式

C22H18O10

主要靶点

COX

仅限科研使用

Cat No : CM00409

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Synonyms

ECG;Epicatechin Gallate;(-)-Epicatechin 3-O-Gallate

验证数据展示

  • CAS No.: 1257-08-5

    (-)-Epicatechin Gallate
    CAS#: 1257-08-5

产品信息

(-)-Epicatechin gallate (ECG) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. (-)-Epicatechin-3-O-gallate (ECG), a component of Rhei Rhizoma, the absolute bioavailability values (F) were 1.02, 1.47 and 3.30% at doses of 12.5, 25.0, and 50.0 mg/kg, respectively. And oral administration of ECG, ECG plasma levels revealed curves characterized by peaks at 0.065, 0.063 and 0.085 h.(-)-Epicatechin gallate(ECG) (25 μg ml−1) suppresses the secretion of coagulase and α-toxin by clinical isolates of S. aureus(Staphylococcus aureus ).

CAS号 1257-08-5
分子式 C22H18O10
主要靶点 COX
主要通路 Natural Product
分子量 442.3723
MDL NO MFCD00075936
Pubchem ID 107905
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 ECG;Epicatechin Gallate;(-)-Epicatechin 3-O-Gallate

靶点

TargetActivity
COX1IC50=7.5μM

溶解度

DMSO88 mg/mL
WaterInsoluble
Ethanol88 mg/mL

参考文献

1Malik S, Suchal K, Bhatia J, Gamad N, Dinda AK, Gupta YK, Arya DS. Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate. Lab Invest. 2016 Aug;96(8):853-61.
2Shiota S, Shimizu M, et al. Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biol Pharm Bull. 1999 Dec;22(12):1388-90.

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The dilution calculator equation

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