Recombinant Human Cadherin-13 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Cadherin-13 protein Ser139-Gly693 (Accession# P55290-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1012 |
| 蛋白编号 | P55290-1 |
| 预测分子量 | 86.4 kDa |
| SDS-PAGE | 90-115 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cadherin-13 (CDH13, also known as H-cadherin or T-cadherin) is an atypical member of cadherin family, lacking transmembrane and cytosolic domains and anchored to the exterior surface of the plasma membrane via a GPI anchor. CDH13 is thought to affect cellular behavior largely through its signaling properties. It is highly expressed in heart, and in the CNS, CDH13 is expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. It is often down-regulated in cancerous cells.
参考文献:
1. Philippova, Maria et al. Cellular signalling vol. 21,7 (2009): 1035-44. 2. Paredes, Joana et al. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 11,16 (2005): 5869-77. 3. Xu, Yidong et al. Experimental and therapeutic medicine vol. 18,1 (2019): 841-847.
