Recombinant Mouse Leptin protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Leptin protein Val22-Cys167 (Accession# Q544U0) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 16846 |
| 蛋白编号 | Q544U0 |
| 预测分子量 | 43.2 kDa |
| SDS-PAGE | 40-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Leptin is a 16 kDa adipocyte-derived hormone, and it has attracted interest in the field of obesity research due to its role in the regulation of energy balance. Leptin, secreted from adipose tissues in proportion to the fat store, acts in the hypothalamus to regulate feeding behavior. leptin has also been shown to play an essential role in tumorigenesis, tumor progression, and metastasis, due to its oncogenic, mitogenic, pro-inflammatory, and pro-angiogenic actions. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. Leptin has also been linked to type 2 diabetes mellitus development.
参考文献:
1. Arnold M.et al. (2016) Cancer Epidemiol.41:8-15. 2. Zhang Y.et al. (1994) Nature.37:425-32. 3. deLuis DA.et al. (2009) Minerva Med.229-36. 4.Jiang N.et al.(2014) Drug Des Devel Ther.8:2295-302. 5. Vansaun MN.et al.(2013) Clin Cancer Res.19:1926-1932.
