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Recombinant Human CD73 protein (rFc Tag)

种属

Human

纯度

>85 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2974

Print datasheet

Synonyms

NT5E, 5 NT, 5 nucleotidase, 5' nucleotidase, ecto (CD73), 5'-deoxynucleotidase

验证数据展示

  • Purity of Recombinant Human CD73 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD73 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >85 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CD73 protein Trp27-Lys547 (Accession# P21589-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 4907
蛋白编号 P21589-1
预测分子量 83.8 kDa
SDS-PAGE 80-95 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD73, also known as ecto-5'-nucleotidase (5'-NT), is a 70-kDa, glycosyl-phosphatidylinositol-linked membrane-bound glycoprotein found in most tissues . CD73 is an ectoenzyme that catalyzes the dephosphorylation of AMP and other nucleoside monophosphates. In the human immune system, CD73 is expressed on subsets of T and B cells, on germinal center follicular dendritic cells, and on thymic medullary reticular fibroblasts and epithelial cells. CD73 is highly expressed in many human solid tumors and is closely involved in cancer progression .

参考文献:

1.Colgan, Sean P et al. Purinergic signalling vol. 2,2 (2006): 351-60.
2.Jin, Dachuan et al. Cancer research vol. 70,6 (2010): 2245-55.
3.Resta, R et al. Immunological reviews vol. 161, (1998): 95-109.
4.Thomson, L F et al. Tissue antigens vol. 35,1 (1990): 9-19. 
5.Jin, Dachuan et al. Cancer research vol. 70,6 (2010): 2245-55.
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