Recombinant Human IL-25/IL-17E protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IL-25 protein Tyr33-Gly177 (Accession# Q9H293-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 64806 |
| 蛋白编号 | Q9H293-1 |
| 预测分子量 | 42.3 kDa |
| SDS-PAGE | 43-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Interleukin-25 (IL-25), also known as IL-17E, is a unique member of the interleukin-17 (IL-17) cytokine family. IL-25 is a key orchestrator of type 2 immune responses, which are central to host defense against helminths, the pathogenesis of allergic disorders, and tissue repair. Its expression is not confined to classical immune cells but is notably abundant in various epithelial cell lineages, positioning it as a critical sentinel at mucosal barriers. IL-25 is critically involved in allergic disorders such as asthma, allergic rhinitis, and chronic rhinosinusitis with nasal polyps (CRSwNP). Its levels in induced sputum correlate with disease severity, eosinophil counts, and lung function in asthmatic children. IL-25 exhibits a dual and complex role in oncology. In colorectal cancer (CRC), its expression correlates with poor survival. Conversely, in breast cancer, serum IL-25 levels are lower in patients compared to healthy subjects, and reduced IL-25 is associated with higher tumor grade and stage.
参考文献:
1.Yuan, Qingfang et al. Biomarker research vol. 11,1 (2023): 36. 2.Ji, Ming et al. Nature vol. 529,7585 (2016): 221-5. 3.Abdu, Semah et al. Allergy vol. 80,4 (2025): 965-975. 4.Zhao, Zewei et al. Frontiers in immunology vol. 13, (2022): 837262. 5.Shokrollahi Barough, Mahdieh et al. J Interferon Cytokine Res vol. 40,3 (2020): 139-144.
