Recombinant Human CCR6 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
C-rFc
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CCR6 protein Ser181-Lys211 (Accession# P51684) with a rabbit IgG Fc tag at the C-terminus |
| 基因ID | 1235 |
| 蛋白编号 | P51684 |
| 预测分子量 | 30.0 kDa |
| SDS-PAGE | 30-40 kDa, reducing (R) condition |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CCR6, also known CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed on most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).
参考文献:
1. Williams IR. et al. (2006). Ann N Y Acad Sci. 1072:52-61. 2. Baba M. et al. (1997). J Biol Chem. 272(23):14893-14898. 3. Schutyser E. et al. (2003). Cytokine Growth Factor Rev. 14(5):409-426. 4. Kochi Y. et al. (2010). Nat Genet. 42(6):515-519.
